CAS No. 230615-23-3
Batch:
Purity:99.95
Chemical Structure
Check the
Varenicline Hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 230615-23-3 | |
|---|---|---|
| Molecular Formula |
C13H14ClN3 |
|
| Molecular Weight (MW) | 247.72 | |
| SMILES | Cl.C1NCC2CC1C3=CC4=NC=CN=C4C=C23 |
Varenicline Hydrochloride is a selective partial agonist of α4β2 and α6β2 nicotinic acetylcholine receptors (nAChRs). By binding to neuronal nAChRs, it modulates central cholinergic neurotransmission and regulates mesolimbic dopamine signaling pathways. This partial agonism produces moderate activation of downstream dopamine release while simultaneously inhibiting full agonist activity, thereby attenuating mesolimbic reward circuitry and modulating neuronal excitability. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 50 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Varenicline Hydrochloride Solubility in DMSO
- Varenicline Hydrochloride Stock Solution
- Varenicline Hydrochloride Storage
- Varenicline Hydrochloride Stability
- Varenicline Hydrochloride Molecular Weight
- Varenicline Hydrochloride SMILES
- Varenicline Hydrochloride Chemical Structure (2D and 3D)
- Varenicline Hydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.