CAS No. 2451-62-9

Batch: Purity:99.52
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Triglycidyl Isocyanurate (Teroxirone) Chemical Structure
Chemical Structure
Check the Triglycidyl Isocyanurate (Teroxirone) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 2451-62-9
Molecular Formula

C12H15N3O6
Molecular Weight (MW) 297.26
SMILES C1C(O1)CN2C(=O)N(C(=O)N(C2=O)CC3CO3)CC4CO4

Biological Activity

Triglycidyl Isocyanurate (Teroxirone) is a triazene triepoxide alkylating compound with antineoplastic activity. It functions by covalently alkylating and cross-linking DNA, which directly disrupts DNA replication and genomic stability. This induced DNA damage activates the p53 pathway, subsequently promoting downstream cell cycle arrest and apoptotic cell death to inhibit human non-small cell lung cancer cell growth. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 59 mg/mL (198.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Cancer Chemother. Pharmacol. 1980;4(2).

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Note: Technical data last updated: Sep 1, 2026.