CAS No. 627908-92-3

Batch: Purity:99.68
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SU14813 Chemical Structure
Chemical Structure
Check the SU14813 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-(2-hydroxy-3-morpholin-4-ylpropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
CAS Number 627908-92-3
Molecular Formula

C23H27FN4O4
Molecular Weight (MW) 442.48
SMILES CC1=C(NC(=C1C(=O)NCC(CN2CCOCC2)O)C)C=C3C4=C(C=CC(=C4)F)NC3=O
InChIKey CTNPALGJUAXMMC-ZDLGFXPLSA-N

Ordering Information

Biological Activity

SU14813 is a multi-targeted receptor tyrosine kinase inhibitor that targets VEGFR1 (IC50 2 nM), PDGFRβ (IC50 4 nM), Kit (IC50 15 nM), and VEGFR2 (IC50 50 nM). By suppressing receptor autophosphorylation and downstream RTK signaling cascades, it impairs endothelial cell proliferation, vascular permeability, and tumor angiogenesis. These cellular actions suppress tumor growth and induce regression across diverse xenograft models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 88 mg/mL (198.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.