CAS No. 242478-37-1

Batch: Purity:99.83
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Solifenacin (YM905) Chemical Structure
Chemical Structure
Check the Solifenacin (YM905) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 242478-37-1
Molecular Formula

C23H26N2O2
Molecular Weight (MW) 362.46
SMILES C1CN2CCC1C(C2)OC(=O)N3CCC4=CC=CC=C4C3C5=CC=CC=C5

Biological Activity

Solifenacin (YM905) is a potent competitive muscarinic receptor antagonist that demonstrates higher affinity for muscarinic M3 receptors compared to M2 receptors. By blocking endogenous acetylcholine binding to M3 receptors, it disrupts downstream muscarinic signaling pathways. This targeted receptor antagonism effectively suppresses cholinergic smooth muscle contraction and attenuates detrusor muscle overactivity in tissue models. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 72 mg/mL (198.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Ikeda K, et al. Naunyn Schmiedebergs Arch Pharmacol. 2002;366(2):97-103.

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Note: Technical data last updated: Sep 1, 2026.