CAS No. 1628106-94-4

Batch: Purity:99.72
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Sofpironium bromide Chemical Structure
Chemical Structure
Check the Sofpironium bromide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(3R)-1-(2-ethoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium-3-yl] (2R)-2-cyclopentyl-2-hydroxy-2-phenylacetate bromide
CAS Number 1628106-94-4
Molecular Formula

C22H32NO5.Br
Molecular Weight (MW) 470.40
InChIKey FIAFMTCUJCWADZ-JOFREBOKSA-M

Biological Activity

Sofpironium bromide is an anticholinergic agent that acts as a targeted inhibitor of M3 muscarinic acetylcholine receptors. By selectively blocking acetylcholine binding to M3 muscarinic receptors on eccrine sweat glands, it disrupts cholinergic signal transduction required for sweat gland activation. Consequently, this competitive antagonism suppresses muscarinic signaling pathways, inhibiting localized glandular secretion and reducing sweat production. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 94 mg/mL (199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 94 mg/mL
Ethanol 94 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Paik J. Drugs. 2020;80(18):1981-1986.

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Note: Technical data last updated: Sep 1, 2026.