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LDH

Isoform-selective Products

LDH Products

All (9)
LDH Inhibitors (7)
LDH Activator (1)
LDH Modulator (1)
New LDH Products

Catalog No.	Product Name	Information	Product Use Citations	Product Validations
S6871	Sodium oxamate	Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.	J Adv Res, 2024, S2090-1232(24)00025-0 Invest Ophthalmol Vis Sci, 2024, 65(3):37 Theranostics, 2023, 13(11):3856-3871
S6675	(R)-GNE-140	(R)-GNE-140 is a selective inhibitor of the LDHA and LDHB with IC50s of 3 nM and 5 nM, respectively. The R enantiomer of GNE-140 is 18-fold more potent than S enantiomer.	J Cachexia Sarcopenia Muscle, 2023, 10.1002/jcsm.13363 J Virol, 2022, jvi0197421
S0108	AZ-33	AZ-33 (LDHA Inhibitor 33) is a potent inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 0.5 μM. LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.	FASEB J, 2022, 36(3):e22229 Front Mol Biosci, 2021, 8:806650
S8590	GSK 2837808A	GSK2837808A is a selective LDHA (lactate dehydrogenase A) inhibitor with IC50 of 2.6 nM and 43 nM for hLDHA and hLDHB, respectively.	Nat Neurosci, 2022, 25(7):865-875
S3143	Pyruvic acid	Pyruvic acid (Acetylformic acid) is an important organic chemical intermediate that plays a role in cardiomyocyte pathophysiology and therapy. Pyruvic acid markedly increases the level of lactate dehydrogenase (LDH) and creatine kinase (CK) and reduces the level of Ca²⁺Mg²⁺-ATPase and Na⁺K⁺-ATPase.
E3731	Chinese Gallnut Extract	Chinese Gallnut Extract is obtained from Melaphis chinensis gallnut, which is the most potent inhibitor of human Lactate dehydrogenase (LDH)-A in the high-throughput screening study of 905 natural products.
S8928	FX11	FX-11(LDHA Inhibitor FX11) is a potent inhibitor of lactate dehydrogenase A (LDHA)) with IC50 of 49.27 μM in BxPc-3 cells.
S4441	Isomalt	Isomalt (Palatinitol) is a sugar alcohol used as an excipient in commercially available solid oral dosage forms. Isomalt stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying.
S9606	Galloflavin	Galloflavin (NSC 107022) is a novel inhibitor of lactate dehydrogenasee (LDH) with Ki values of 5.46 μM and 15.06 μM for LDH-A and LDH-B, respectively.	J Virol, 2024, 98(1):e0167023
S6871	Sodium oxamate	Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.	J Adv Res, 2024, S2090-1232(24)00025-0 Invest Ophthalmol Vis Sci, 2024, 65(3):37 Theranostics, 2023, 13(11):3856-3871
S6675	(R)-GNE-140	(R)-GNE-140 is a selective inhibitor of the LDHA and LDHB with IC50s of 3 nM and 5 nM, respectively. The R enantiomer of GNE-140 is 18-fold more potent than S enantiomer.	J Cachexia Sarcopenia Muscle, 2023, 10.1002/jcsm.13363 J Virol, 2022, jvi0197421
S0108	AZ-33	AZ-33 (LDHA Inhibitor 33) is a potent inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 0.5 μM. LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.	FASEB J, 2022, 36(3):e22229 Front Mol Biosci, 2021, 8:806650
S8590	GSK 2837808A	GSK2837808A is a selective LDHA (lactate dehydrogenase A) inhibitor with IC50 of 2.6 nM and 43 nM for hLDHA and hLDHB, respectively.	Nat Neurosci, 2022, 25(7):865-875
E3731	Chinese Gallnut Extract	Chinese Gallnut Extract is obtained from Melaphis chinensis gallnut, which is the most potent inhibitor of human Lactate dehydrogenase (LDH)-A in the high-throughput screening study of 905 natural products.
S8928	FX11	FX-11(LDHA Inhibitor FX11) is a potent inhibitor of lactate dehydrogenase A (LDHA)) with IC50 of 49.27 μM in BxPc-3 cells.
S9606	Galloflavin	Galloflavin (NSC 107022) is a novel inhibitor of lactate dehydrogenasee (LDH) with Ki values of 5.46 μM and 15.06 μM for LDH-A and LDH-B, respectively.	J Virol, 2024, 98(1):e0167023
S3143	Pyruvic acid	Pyruvic acid (Acetylformic acid) is an important organic chemical intermediate that plays a role in cardiomyocyte pathophysiology and therapy. Pyruvic acid markedly increases the level of lactate dehydrogenase (LDH) and creatine kinase (CK) and reduces the level of Ca²⁺Mg²⁺-ATPase and Na⁺K⁺-ATPase.
S4441	Isomalt	Isomalt (Palatinitol) is a sugar alcohol used as an excipient in commercially available solid oral dosage forms. Isomalt stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying.

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