Home Metabolism LDH

LDH

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S6871 Sodium oxamate Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. This compound induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.
Adv Sci (Weinh), 2025, 12(8):e2411943
Nucleic Acids Res, 2025, 53(17)gkaf882
Cell Rep Med, 2025, 6(8):102292
S6675 (R)-GNE-140 (R)-GNE-140 is an inhibitory agent for LDHA, LDHB, and LDHC, with IC50 values ​​of 3 nM and 5 nM for LDHA and LDHB, respectively. (R)-GNE-140 is 18 times more potent than its S isomer.
J Clin Invest, 2024, 134(17)e177606
J Mol Cell Biol, 2024, mjae056
J Cachexia Sarcopenia Muscle, 2023, 10.1002/jcsm.13363
S0108 AZ-33 AZ-33 (LDHA Inhibitor 33) is a potent inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 0.5 μM. LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.
FASEB J, 2022, 36(3):e22229
Front Mol Biosci, 2021, 8:806650
E4772 LDHA-IN-3 LDHA-IN-3, a selenobenzene derivative, is a potent noncompetitive inhibitor of Lactate Dehydrogenase A (LDHA), with an IC50 of 145.2 nM. It exhibits significant anti-tumor activity, effectively reducing LDHA activity and lactate production under both normoxic and hypoxic conditions. It also induces mitochondria-mediated apoptosis through the generation of reactive oxygen species.
S3143 Pyruvic acid

Pyruvic acid (Acetylformic acid) is an important organic chemical intermediate that plays a role in cardiomyocyte pathophysiology and therapy. This compound markedly increases the level of lactate dehydrogenase (LDH) and creatine kinase (CK) and reduces the level of Ca2+Mg2+-ATPase and Na+K+-ATPase.
E3731 Chinese Gallnut Extract Chinese Gallnut Extract is obtained from Melaphis chinensis gallnut, which is the most potent inhibitor of human Lactate dehydrogenase (LDH)-A in the high-throughput screening study of 905 natural products.
S8928 FX11 FX-11(LDHA Inhibitor FX11) is a potent inhibitor of lactate dehydrogenase A (LDHA)) with IC50 of 49.27 μM in BxPc-3 cells.
Theranostics, 2025, 15(7):3055-3075
Cell Death Dis, 2025, 16(1):574
Cell Metab, 2024, S1550-4131(24)00415-7
S4441 Isomalt Isomalt (Palatinitol) is a sugar alcohol used as an excipient in commercially available solid oral dosage forms. This compound stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying.
S9606 Galloflavin Galloflavin (NSC 107022) is a novel inhibitor of lactate dehydrogenasee (LDH) with Ki values of 5.46 μM and 15.06 μM for LDH-A and LDH-B, respectively.
J Virol, 2024, 98(1):e0167023
S8590 GSK 2837808A GSK2837808A is a selective LDHA (lactate dehydrogenase A) inhibitor with IC50 of 2.6 nM and 43 nM for hLDHA and hLDHB, respectively.
Cancer Commun (Lond), 2025, 10.1002/cac2.70036
EMBO Rep, 2025, 10.1038/s44319-025-00573-8
Nat Neurosci, 2022, 25(7):865-875