Sodium oxamate Mechanism of Action: LDHA Inhibition in Cancer Cell Research

Sodium oxamate MOA:Targeting LDHA/Aerobic Glycolysis for Cancer Metabolism and Immunotherapy

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Sodium oxamate is a competitive LDHA inhibitor. It affects PI3K/Akt/mTOR and HIF1α signaling pathways by blocking pyruvate-to-lactate conversion and reducing histone lactylation, effectively inhibiting tumor cell proliferation and migration, and promoting apoptosis.

Primary Applications and Mechanism of Action