Propafenone

Catalog No.S5789 Batch:S578901

Technical Data

Formula	C₂₁H₂₇NO₃
Molecular Weight	341.44	CAS No.	54063-53-5
Solubility (25°C)*	In vitro	DMSO	68 mg/mL (199.15 mM)
		Ethanol	41 mg/mL (120.07 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description

Propafenone (SA-79) is an orally active sodium channel blocking agent and a beta-adrenoceptor (β-adrenergic receptor) antagonist. Propafenone offers a broad spectrum of activity in the treatment of cardiac arrhythmias.

Targets

sodium channel ^[1]

β-adrenergic receptor ^[1]

In vitro

Application of 10 µM propafenone decreases the Kv currents by 51%, as measured at +60 mV.^[2]

Protocol (from reference)

Cell Assay:^{^[2]}	Cell lines coronary arterial smooth muscle cells Concentrations 10 µM Incubation Time 2 min Method Tail currents, which were induced by a returning potential of −40 mV after short (20–50 ms ms) depolarizing steps from −80 to +60 mV in 10 mV increments, were used to obtain the steady-state activation curves. The recorded tail currents for each potential were normalized to the maximal tail current. Currents were recorded with a 600-ms test potential of +40 mV after 7-s pre-conditioning steps from −80 mV to +30 mV (10 mV increments) in the absence and presence of propafenone.

Cell Assay:^{^[2]}

Cell lines
coronary arterial smooth muscle cells
Concentrations
10 µM
Incubation Time
2 min
Method
Tail currents, which were induced by a returning potential of −40 mV after short (20–50 ms ms) depolarizing steps from −80 to +60 mV in 10 mV increments, were used to obtain the steady-state activation curves. The recorded tail currents for each potential were normalized to the maximal tail current. Currents were recorded with a 600-ms test potential of +40 mV after 7-s pre-conditioning steps from −80 mV to +30 mV (10 mV increments) in the absence and presence of propafenone.

References

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SHIPPING AND STORAGE
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