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Parsaclisib (INCB050465) PI3K inhibitor

Name: Parsaclisib (INCB050465)
Brand: Selleck Chemicals
SKU: E0121
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E0121

Parsaclisib (INCB050465, INCB-50465, IBI376) is a potent and highly selective PI3Kδ(PI3K delta) inhibitor with an IC50 of 1 nM at 1 mM ATP in biochemical assay and approximately 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.

Chemical Structure

Molecular Weight: 432.88

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Quality Control

Batch: E012101 DMSO]100 mg/mL]false]]]false]]]false Purity: 99.99%

Cited in Nature Medicine for its top-tier quality
COA
SDS/MSDS
Datasheet

99.99

Related Targets	Akt mTOR GSK-3 ATM/ATR DNA-PK AMPK PDPK1 PTEN PI4K PP2A
Other PI3K Inhibitors	GDC-0077 (Inavolisib) SAR405 Quercetin (Sophoretin) LY294002 XL147 analogue Tersolisib (STX-478) Buparlisib (BKM120) 740 Y-P (PDGFR 740Y-P) GO-203 TFA Eganelisib (IPI-549)

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (231.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5mg/ml (11.55mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.71mg/ml (1.64mM)	Taking the 1 mL working solution as an example, add 50 μL of 14.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	432.88	Formula	C₂₀H₂₂ClFN₆O₂	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	1426698-88-5	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	INCB-50465, IBI376			SMILES	CCOC1=C(C2CNC(=O)C2)C(=C(Cl)C=C1C(C)[N]3N=C(C)C4=C(N)N=CN=C34)F

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	PI3Kδ (in biochemical assay) 1 nM
References	[1] https://cancerres.aacrjournals.org/content/75/15_Supplement/2671.short

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2022-04-29)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04849715	WITHDRAWN	Mantle Cell Lymphoma	Incyte Corporation	2022-03-11	PHASE3
NCT05867030	WITHDRAWN	Follicular Lymphoma	Innovent Biologics (Suzhou) Co. Ltd.	2023-07-28	PHASE1
NCT04796922	WITHDRAWN	Follicular Lymphoma ( FL); Marginal Zone Lymphoma (MZL)	Incyte Corporation	2022-12-30	PHASE3
NCT04509700	ACTIVE_NOT_RECRUITING	B-Cell Malignancies	Incyte Corporation	2020-08-03	PHASE2
NCT04661007	ACTIVE_NOT_RECRUITING	Non Hodgkins Lymphoma; Diffuse Large B-cell Lymphoma	Incyte Biosciences Japan GK	2020-12-15	PHASE1; PHASE2
NCT05238064	UNKNOWN	PI3Kδ Inhibitor; Parsaclisib; CHOP; PTCL	Fudan University	2022-03	PHASE1; PHASE2

Tech Support

Handling Instructions

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