CAS No. 1426698-88-5

Batch: Purity:99.99
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Parsaclisib (INCB050465) Chemical Structure
Chemical Structure
Check the Parsaclisib (INCB050465) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (4R)-4-[3-[(1S)-1-(4-amino-3-methylpyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl]pyrrolidin-2-one
CAS Number 1426698-88-5
Molecular Formula

C20H22ClFN6O2
Molecular Weight (MW) 432.88
SMILES CCOC1=C(C2CNC(=O)C2)C(=C(Cl)C=C1C(C)[N]3N=C(C)C4=C(N)N=CN=C34)F
InChIKey ZQPDJCIXJHUERQ-QWRGUYRKSA-N

Biological Activity

Parsaclisib (INCB050465) is a potent and highly selective inhibitor of phosphoinositide 3-kinase delta (PI3Kδ), exhibiting over-fold selectivity against other class I PI3K isozymes. By directly targeting PI3Kδ and inhibiting downstream PI3K/AKT/mTOR pathway signaling, it blocks tumor cell proliferation in B-cell malignancies and lessens regulatory T-cell-mediated immunosuppression to control tumor growth in preclinical models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (231.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Yue EW, et al. ACS Med Chem Lett. 2019;10(11):1554-1560.

[2] Shin N, et al. J Pharmacol Exp Ther. 2020;374(1):211-222.

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Note: Technical data last updated: Sep 1, 2026.