CAS No. 920868-45-7
Batch:
Purity:99.46
Chemical Structure
Check the
MASM7
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[2-[(5-cyclopropyl-4-phenyl-1,2,4-triazol-3-yl)sulfanyl]propanoylamino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide | |
|---|---|---|
| CAS Number | 920868-45-7 | |
| Molecular Formula |
C22H23N5O2S2 |
|
| Molecular Weight (MW) | 453.58 | |
| InChIKey | MTAWXPCGCQTSOJ-UHFFFAOYSA-N |
MASM7 is a small-molecule activator of mitofusins that promotes mitofusin-mediated mitochondrial fusion. By directly binding to the heptad repeat 2 (HR2) domain of mitofusin 2 (MFN2), it enhances mitochondrial aspect ratio and induces organelle fusion. Activators targeting mitofusins regulate mitochondrial network dynamics, restoring mitochondrial morphology and supporting cellular bioenergetics across various eukaryotic cell models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(110.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.