CAS No. 6106-07-6

Batch: Purity:99.57
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L-Thyroxine sodium salt pentahydrate Chemical Structure
Chemical Structure
Check the L-Thyroxine sodium salt pentahydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 6106-07-6
Molecular Formula

C15H20I4NNaO9
Molecular Weight (MW) 888.93

Biological Activity

L-Thyroxine sodium salt pentahydrate is a synthetic thyroid hormone (T4) that acts as an agonist at thyroid hormone receptors. Upon binding to nuclear thyroid hormone receptors, it regulates gene expression involved in metabolic processes, growth, and cellular differentiation. In preclinical research, it is widely utilized to establish animal models of hyperthyroidism and to counteract hypothyroid states by activating thyroid hormone receptor-mediated signaling pathways. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (112.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Nat Rev Cancer. 2010;10(12):813-813.

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Note: Technical data last updated: Sep 1, 2026.