L-Glutamic acid monosodium salt

Catalog No.S4721 Batch:S472101

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Technical Data

Formula

C5H8NO4.Na
Molecular Weight 169.11 CAS No. 142-47-2
Solubility (25°C)* In vitro Water 33 mg/mL (195.13 mM)
DMSO Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods. L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
In vitro Monosodium glutamate(MSG) induces apoptosis in human B cells. It has a more potent apoptotic effect in naïve B cells compared to memory B cell population[3]. Low doses of L-monosodium glutamate promote neuronal growth and differentiation in vitro[4].
In vivo Daily monosodium glutamate(MSG) dietary consumption reduces pancreatic β-cell mass and enhances hemorrhages and fibrosis, but does not affect glucose homeostasis. High dietary MSG intake may exert a negative effect on the pancreas and such effect might become functionally significant in the presence or susceptibility to diabetes or NaCl. Parenteral MSG causes various changes in pancreatic islets such as hypertrophy, hyperplasia, decrease in acinar cells, α-cells and somatostatin cells and increase in fibrosis[1]. MSG may have some deleterious effects on the testes of Wistar rats and by extension may contribute to the causes of male infertility[2].

Protocol (from reference)

Cell Assay:[3]
  • Cell lines

    human B cells

  • Concentrations

    1-100 mM

  • Incubation Time

    24 h

  • Method

    B cells are cultured with and with out increasing concentrations of MSG(1-100 mM) for 24 h. The number of early apoptotic cells and necrotic cells is determined using Annexin-V FITC/PI staining.

Animal Study:[1]
  • Animal Models

    Adult male Wistar rats

  • Dosages

    2 mg/g 

  • Administration

    Oral administration

Selleck's L-Glutamic acid monosodium salt has been cited by 2 publications

SREBP1 deficiency diminishes glutamate-mediated HT22 cell damage and hippocampal neuronal pyroptosis induced by status epilepticus [ Heliyon, 2024, 10(1):e23945] PubMed: 38205297
Soft substrates promote direct chemical reprogramming of fibroblasts into neurons [ Acta Biomater, 2022, 152:255-272] PubMed: 36041647

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.