IMM-H007

Catalog No.S4460

For research use only.

IMM-H007, an adenosine derivative, is an activator of AMP-Activated Protein Kinase (AMPK). IMM-H007 is a potential drug for treating cardiac dysfunction. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 (ATP binding cassette subfamily a member 1) degradation and facilitates its cell-surface localization in macrophages, thereby promotes cholesterol efflux.

IMM-H007 Chemical Structure

CAS No. 1221412-23-2

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Biological Activity

Description IMM-H007, an adenosine derivative, is an activator of AMP-Activated Protein Kinase (AMPK). IMM-H007 is a potential drug for treating cardiac dysfunction. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 (ATP binding cassette subfamily a member 1) degradation and facilitates its cell-surface localization in macrophages, thereby promotes cholesterol efflux.
Targets
AMPK [1] NF-κB [2] JNK/AP1 [3] ABCA1 [3]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 485.45
Formula

C22H23N5O8

CAS No. 1221412-23-2
Storage 3 years -20°C powder
2 years -80°C in solvent

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