CAS No. 125-04-2

Batch: Purity:99.05
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Hydrocortisone sodium succinate Chemical Structure
Chemical Structure
Check the Hydrocortisone sodium succinate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name sodium 4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoate
CAS Number 125-04-2
Molecular Formula

C25H33O8.Na
Molecular Weight (MW) 484.51
SMILES [Na+].CC12CCC(=O)C=C1CCC3C4CCC(O)(C(=O)COC(=O)CCC([O-])=O)C4(C)CC(O)C23
InChIKey HHZQLQREDATOBM-CODXZCKSSA-M

Ordering Information

Biological Activity

Hydrocortisone sodium succinate is a steroidal anti-inflammatory compound that potently suppresses interleukin-6 (IL-6) bioactivity with an IC50 of 6.7 µM. Through the modulation of cytokine-driven regulatory cascades, it inhibits downstream pro-inflammatory and hematopoietic signaling pathways. This inhibition reduces inflammatory mediator activation and suppresses cell proliferation in IL-6-dependent cellular models, thereby driving broad anti-inflammatory and immunosuppressive phenotypic responses. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 97 mg/mL (200.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 97 mg/mL
Ethanol 2 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.