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Flecainide

Cat.No.E0528

Flecainide is a common medication used to help restore and maintain sinus rhythm in patients with atrial fibrillation.
Flecainide Chemical Structure

Chemical Structure

Molecular Weight: 414.34

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: E052801 DMSO]83 mg/mL]false]Ethanol]21 mg/mL]false]Water]Insoluble]false Purity: 99.64%
99.64

Chemical Information, Storage & Stability

Molecular Weight 414.34 Formula

C17H20F6N2O3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 54143-55-4 -- Storage of Stock Solutions

Solubility

In vitro
Batch:

DMSO : 83 mg/mL (200.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 21 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
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μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04991896 Completed
Atrial Fibrillation|Arrhythmias Cardiac
AHEPA University Hospital|Skylitseio General Hospital
 January 1 2020 --
NCT03685149 Completed
Arrhythmogenic Right Ventricular Cardiomyopathy
Wojciech Zareba|University of Rochester
 July 31 2019 Phase 2
NCT03005366 Completed
Paroxysmal Atrial Fibrillation
David Filgueiras-Rama|Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III|Hospital San Carlos Madrid
 January 2017 Phase 4
NCT02190175 Completed
Atrial Fibrillation
Hellenic Cardiovascular Research Society
 June 2014 --
NCT00945867 Unknown status
Atrial Fibrillation
Assaf-Harofeh Medical Center
 September 2009 --

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