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DRB18 GLUT inhibitor

Name: DRB18
Brand: Selleck Chemicals
SKU: S9636
Availability: InStock
Rating: 5 (2 reviews)

Cat.No.S9636

DRB18 is a pan-GLUT (glucose transporters) inhibitor that inhibits growth and proliferation in several different cancer types with IC50 high nM range.

Chemical Structure

Molecular Weight: 382.88

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Quality Control

Batch: S963601 DMSO]76 mg/mL]false]Ethanol]76 mg/mL]false]Water]Insoluble]false Purity: 99.10%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS
Datasheet

99.10

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism
Other GLUT Products	BAY-876 STF-31 WZB117 Glut1 Antibody [C8B12] GLUT4 Antibody [H5N16] KL-11743 Glut4 Antibody [G3B7] AS160 Antibody [L14F10] MUC16 Antibody [B21H3] Glucose Transporter GLUT2 Antibody [E14F15]

Solubility

In vitro
Batch:

DMSO : 76 mg/mL (198.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 76 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	4.000mg/ml (10.45mM)	Taking the 1 mL working solution as an example, add 50 μL of 80 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	4.000mg/ml (10.45mM)

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	382.88	Formula	C₂₂H₂₃ClN₂O₂	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	unknown	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	CC1=CC=C(CNC2=C(NCC3=CC(=C(C)C=C3)O)C=C(Cl)C=C2)C=C1O

Mechanism of Action

Targets/IC₅₀/Ki	GLUT
In vitro	DRB18 inhibits growth and proliferation in about 90% of the 60 different cancer cell lines in 9 major cancer types. Treatment with this compound leads to significant changes in glucose-based metabolism in A549 lung cancer cells, including cell death via ER/oxidative stress and necrosis.
In vivo	DRB18 (10 mg/kg) treatment thrice a week significantly reduces growth in Xenograft A549 tumors.
References	[1] https://cancerres.aacrjournals.org/content/80/16_Supplement/4191 [2] https://pubmed.ncbi.nlm.nih.gov/33771231/

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Handling Instructions

Tel: +1-832-582-8158 Ext:3

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