Home Metabolism GLUT inhibitor DRB18 For research use only.

DRB18

DRB18 is a pan-GLUT (glucose transporters) inhibitor that inhibits growth and proliferation in several different cancer types with IC50 high nM range.

DRB18 Chemical Structure

DRB18 Chemical Structure

CAS: unknown

Selleck's DRB18 has been cited by 2 publications

Purity & Quality Control

Batch: S963601 DMSO] 76 mg/mL] false] Ethanol] 76 mg/mL] false] Water] Insoluble] false Purity: 99.10%
99.10

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Biological Activity

Description DRB18 is a pan-GLUT (glucose transporters) inhibitor that inhibits growth and proliferation in several different cancer types with IC50 high nM range.
Targets
GLUT [1]
In vitro
In vitro

DRB18 inhibits growth and proliferation in about 90% of the 60 different cancer cell lines in 9 major cancer types. DRB18 treatment leads to significant changes in glucose-based metabolism in A549 lung cancer cells, including cell death via ER/oxidative stress and necrosis.[1]
Cell Research Cell lines HeLa cells
Concentrations 1.3 µM
Incubation Time 24 h
Method

Cells were treated with various concentrations of drug for 24 h.
In Vivo
In vivo

DRB18 (10 mg/kg) treatment thrice a week significantly reduces growth in Xenograft A549 tumors.[1]
Animal Research Animal Models Male NU/J nude mice
Dosages 10 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 382.88 Formula

C22H23ClN2O2
CAS No. unknown SDF --
Smiles CC1=CC=C(CNC2=C(NCC3=CC(=C(C)C=C3)O)C=C(Cl)C=C2)C=C1O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 76 mg/mL ( (198.49 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 76 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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