CAS No. 2863686-81-9
Batch:
Purity:99.10
Chemical Structure
Check the
DRB18
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-[[4-chloro-2-[(3-hydroxy-4-methylphenyl)methylamino]anilino]methyl]-2-methylphenol | |
|---|---|---|
| CAS Number | 2863686-81-9 | |
| Molecular Formula |
C22H23ClN2O2 |
|
| Molecular Weight (MW) | 382.88 | |
| SMILES | CC1=CC=C(CNC2=C(NCC3=CC(=C(C)C=C3)O)C=C(Cl)C=C2)C=C1O | |
| InChIKey | WNTAQMQIZGJASL-UHFFFAOYSA-N |
DRB18 is a pan-glucose transporter (pan-GLUT) inhibitor that targets GLUT family-mediated glucose uptake. By blocking GLUT-dependent glucose transport into cancer cells, DRB18 suppresses intracellular glycolytic flux and energy metabolism, thereby impairing cell survival, growth, and proliferation across multiple cancer cell types. This disruption of cellular glucose utilization highlights GLUT inhibition as a viable strategy to target metabolic vulnerability in oncogenesis. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(198.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 76 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.