CAS No. 3254-89-5
Batch:
Purity:99.94
Chemical Structure
Check the
Diphenidol HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 3254-89-5 | |
|---|---|---|
| Molecular Formula |
C21H28ClNO |
|
| Molecular Weight (MW) | 345.91 | |
| SMILES | C1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O.Cl |
Diphenidol HCl is a potent antagonist of muscarinic M2 and M3 receptors. Antagonism of these muscarinic receptor subtypes disrupts downstream G-protein-coupled signaling pathways, inhibiting phospholipase C activity and modulating intracellular calcium mobilization. These molecular events attenuate vestibular excitation and gastrointestinal motility signals, leading to suppressed emetic responses and reduced vertigo phenotypes. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
69 mg/mL
(199.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 36 mg/mL |
| Water | 13 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.