Dianhydrogalactitol (VAL-083)

Catalog No.S6984 Synonyms: Dianhydrodulcitol, Dulcitol Diepoxide

For research use only.

Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. Dianhydrogalactitol shows antitumor activity.

Dianhydrogalactitol (VAL-083) Chemical Structure

CAS No. 23261-20-3

Purity & Quality Control

Choose Selective DNA alkylator Inhibitors

Biological Activity

Description Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. Dianhydrogalactitol shows antitumor activity.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 29 mg/mL
(198.43 mM)
Water 29 mg/mL
(198.43 mM)
Ethanol ''29 mg/mL

Chemical Information

Molecular Weight 146.14
Formula

C6H10O4

CAS No. 23261-20-3
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03281681 Withdrawn Drug: VAL-083 Dianhydrogalactitol Ovarian Cancer DelMar Pharmaceuticals Inc.|Kintara Therapeutics Inc. March 2021 Phase 1|Phase 2
NCT03050736 Active not recruiting Drug: VAL-083 (Dianhydrogalactitol) Glioma|Glioblastoma|Glioblastoma Multiforme|GBM|Brain Cancer Kintara Therapeutics Inc.|Sun Yat-sen University December 17 2017 Phase 2
NCT02717962 Active not recruiting Drug: VAL-083 Dianhydrogalactitol Glioma|Glioblastoma|Glioblastoma Multiforme|GBM|Brain Cancer Kintara Therapeutics Inc. January 20 2017 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Dianhydrogalactitol (VAL-083) | Dianhydrogalactitol (VAL-083) supplier | purchase Dianhydrogalactitol (VAL-083) | Dianhydrogalactitol (VAL-083) cost | Dianhydrogalactitol (VAL-083) manufacturer | order Dianhydrogalactitol (VAL-083) | Dianhydrogalactitol (VAL-083) distributor