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Dianhydrogalactitol (VAL-083) DNA alkylator chemical

Name: Dianhydrogalactitol (VAL-083)
Brand: Selleck Chemicals
SKU: S6984
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S6984

Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. It shows antitumor activity.

Chemical Structure

Molecular Weight: 146.14

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S698401 DMSO]29 mg/mL]false]Water]29 mg/mL]false]Ethanol]29 mg/mL]false Purity: 98.57%

98.57

Related Targets	DNA/RNA Synthesis HDAC Topoisomerase PPAR PARP Sirtuin ATM/ATR Casein Kinase eIF MDM2/MDMX DNA-PK DHFR Telomerase Nucleoside Analog/Antimetabolite Thymidylate Synthase CRISPR/Cas9 RAD51 BMI-1 LIM kinase RNR NUDIX High-mobility Group OGG1 Alkylating Agent MTH1 G-quadruplex SMN FENs WRN Pax
Related Products	Lomeguatrib Methyl methanesulfonate Lobaplatin (D-19466)

Chemical Information, Storage & Stability

Molecular Weight	146.14	Formula	C₆H₁₀O₄	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	23261-20-3	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Dianhydrodulcitol, Dulcitol Diepoxide			Smiles	OC(C(O)C1CO1)C2CO2

Solubility

In vitro
Batch:

DMSO : 29 mg/mL ( (198.43 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 29 mg/mL

Ethanol : 29 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

References	https://cancerres.aacrjournals.org/content/72/8_Supplement/811

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03281681	Withdrawn	Ovarian Cancer	DelMar Pharmaceuticals Inc.\|Kintara Therapeutics Inc.	March 2021	Phase 1\|Phase 2
NCT03050736	Active not recruiting	Glioma\|Glioblastoma\|Glioblastoma Multiforme\|GBM\|Brain Cancer	Kintara Therapeutics Inc.\|Sun Yat-sen University	December 17 2017	Phase 2
NCT02717962	Active not recruiting	Glioma\|Glioblastoma\|Glioblastoma Multiforme\|GBM\|Brain Cancer	Kintara Therapeutics Inc.	January 20 2017	Phase 2

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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