Dianhydrogalactitol (VAL-083)

For research use only.

Catalog No.S6984 Synonyms: Dianhydrodulcitol, Dulcitol Diepoxide

Dianhydrogalactitol (VAL-083) Chemical Structure

CAS No. 23261-20-3

Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. Dianhydrogalactitol shows antitumor activity.

Purity & Quality Control

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Biological Activity

Description Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. Dianhydrogalactitol shows antitumor activity.

Protocol

Solubility (25°C)

In vitro DMSO 29 mg/mL (198.43 mM)
Water 29 mg/mL (198.43 mM)
Ethanol ''29 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 146.14
Formula

C6H10O4

CAS No. 23261-20-3
Storage powder
in solvent
Synonyms Dianhydrodulcitol, Dulcitol Diepoxide

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Molecular Weight Calculator

Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03281681 Withdrawn Drug: VAL-083 Dianhydrogalactitol Ovarian Cancer DelMar Pharmaceuticals Inc.|Kintara Therapeutics Inc. March 2021 Phase 1|Phase 2
NCT03050736 Active not recruiting Drug: VAL-083 (Dianhydrogalactitol) Glioma|Glioblastoma|Glioblastoma Multiforme|GBM|Brain Cancer Kintara Therapeutics Inc.|Sun Yat-sen University December 17 2017 Phase 2
NCT02717962 Active not recruiting Drug: VAL-083 Dianhydrogalactitol Glioma|Glioblastoma|Glioblastoma Multiforme|GBM|Brain Cancer Kintara Therapeutics Inc. January 20 2017 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID