CAS No. 23261-20-3

Batch: Purity:98.57
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Dianhydrogalactitol (VAL-083) Chemical Structure
Chemical Structure
Check the Dianhydrogalactitol (VAL-083) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1S,2R)-1-[(2S)-oxiran-2-yl]-2-[(2R)-oxiran-2-yl]ethane-1,2-diol
CAS Number 23261-20-3
Molecular Formula

C6H10O4
Molecular Weight (MW) 146.14
SMILES OC(C(O)C1CO1)C2CO2
InChIKey AAFJXZWCNVJTMK-GUCUJZIJSA-N

Ordering Information

Biological Activity

Dianhydrogalactitol (VAL-083) is a bi-functional DNA alkylating agent that targets N7 of guanine to form interstrand cross-links. By inducing N7 DNA methylation and structural cross-linking, dianhydrogalactitol inhibits DNA replication and RNA synthesis, leading to persistent DNA strand breaks, robust cell cycle arrest, and apoptotic cell death to exert potent antitumor activity.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 29 mg/mL (198.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 29 mg/mL
Ethanol 29 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.