Home Microbiology Anti-infection chemical Desciclovir For research use only.

Desciclovir

Synonyms: DCV, 6-Deoxyacyclovir, BW A515U

Desciclovir (DCV, 6-Deoxyacyclovir, BW A515U) is a prodrug of the antiherpetic agent acyclovir (ACV) that converted into ACV by xanthine oxidase in humans.

Desciclovir Chemical Structure

Desciclovir Chemical Structure

CAS: 84408-37-7

Purity & Quality Control

Batch: S044301 DMSO] 42 mg/mL] false] Water] 25 mg/mL] false] Ethanol] 3 mg/mL] false Purity: 99.75%
99.75

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Biological Activity

Description Desciclovir (DCV, 6-Deoxyacyclovir, BW A515U) is a prodrug of the antiherpetic agent acyclovir (ACV) that converted into ACV by xanthine oxidase in humans.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04070235 Unknown status
Hepatitis C Chronic
Nanjing Sanhome Pharmaceutical Co. Ltd.
 March 29 2019 Phase 2|Phase 3
NCT03208322 Withdrawn
Hepatitis C
Bristol-Myers Squibb
 November 30 2018 --
NCT03500562 Terminated
Chronic Hepatitis C
Bristol-Myers Squibb
 May 8 2018 --
NCT03071133 Completed
Hepatitis C
Bristol-Myers Squibb
 January 1 2018 --

Chemical Information & Solubility

Molecular Weight 209.21 Formula

C8H11N5O2
CAS No. 84408-37-7 SDF --
Smiles C1=C2C(=NC(=N1)N)N(C=N2)COCCO
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 42 mg/mL ( (200.75 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 25 mg/mL

Ethanol : 3 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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