Home GPCR & G Protein Adenosine Receptor antagonist Derenofylline (SLV320)

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Derenofylline (SLV320) Adenosine Receptor antagonist

Cat.No.S0272

Derenofylline (SLV320) is a selective and potent adenosine A1 antagonist with Ki of 1 nM, and it shows selectivity for adenosine A1 over A2A, A2B, and A3 receptors with Ki of 398 nM, 3981 nM, and 200 nM, respectively.
Derenofylline (SLV320) Adenosine Receptor antagonist Chemical Structure

Chemical Structure

Molecular Weight: 308.38

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Quality Control

Batch: S027201 DMSO]62 mg/mL]false]Ethanol]16 mg/mL]false]Water]Insoluble]false Purity: 99.62%
99.62

Solubility

In vitro
Batch:

DMSO : 62 mg/mL (201.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 16 mg/mL

Water : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 308.38 Formula

C18H20N4O

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 251945-92-3 -- Storage of Stock Solutions

Synonyms N/A SMILES C1CC(CCC1NC2=NC(=NC3=C2C=CN3)C4=CC=CC=C4)O

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC50/Ki
Adenosine A1 receptor
(Cell-free assay)
1 nM(Ki)
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2010-09-17)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00744341 TERMINATED
Acute Decompensated Heart Failure; Renal Dysfunction
Solvay Pharmaceuticals
 2009-02 PHASE2
NCT00744341 Terminated
Acute Decompensated Heart Failure; Renal Dysfunction
Solvay Pharmaceuticals
 2009-02 Phase 2
NCT00160134 COMPLETED
Congestive Heart Failure
Solvay Pharmaceuticals
 2005-01 PHASE2

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