Name: Etrumadenant (AB928)
Brand: Selleck Chemicals
SKU: S9608
Availability: InStock
Rating: 5 (3 reviews)

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Quality Control

Batch: S960801 DMSO]85 mg/mL]false]Ethanol]5 mg/mL]false]Water]Insoluble]false Purity: 99.8%

Cited in Nature Medicine for its top-tier quality
COA
SDS/MSDS
Datasheet

99.8

Related Targets	CXCR Hedgehog/Smoothened PKA Adrenergic Receptor AChR 5-HT Receptor Histamine Receptor Dopamine Receptor Ras KRas
Other Adenosine Receptor Inhibitors	Reversine CGS 21680 HCl ZM241385 SCH58261 Ciforadenant (CPI-444) A2AR antagonist 1 Imaradenant (AZD4635) DPCPX SCH-442416 Namodenoson (CF-102)

Solubility

In vitro
Batch:

DMSO : 85 mg/mL (199.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	4.250mg/ml (9.97mM)	Taking the 1 mL working solution as an example, add 50 μL of 85 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.700mg/ml (1.64mM)	Taking the 1 mL working solution as an example, add 50 μL of 14 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	426.47	Formula	C₂₃H₂₂N₈O	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	2239273-34-6	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	A2aR/A2bR antagonist-1			SMILES	CC1=C(C=CC=C1C2=CC(=NC(=N2)N)C3=CN(N=N3)CC4=NC(=CC=C4)C(C)(C)O)C#N

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	A2AR (Cell-free assay) 1.4 nM(Kd) A2bR (Cell-free assay) 2 nM(Kd)
In vitro	Consistent with the ability of adenosine to suppress immune function, Etrumadenant (AB928) inhibits its suppression of CD4 or CD8 T cell activation.
In vivo	Etrumadenant (AB928) alone has a small but significant effect on reducing the growth rate of established AT-3-OVA tumors. Concurrent treatment with this compound and chemotherapy results in significantly reduced tumor growth rates, when compared to chemotherapy alone.
References	[1] https://pubmed.ncbi.nlm.nih.gov/30569245/ [2] https://pdfs.semanticscholar.org/a660/2b51c93ba219e56658c7dfd3b128f807c958.pdf

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-06-01)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05633667	ACTIVE_NOT_RECRUITING	Lung Cancer; Advanced or Metastatic Non-Small-Cell Lung Cancer; Resectable Non-Small-Cell Lung Cancer	Gilead Sciences	2023-03-16	PHASE2
NCT05335941	ACTIVE_NOT_RECRUITING	Urothelial Carcinoma; Metastatic Cancer	M.D. Anderson Cancer Center	2023-06-13	PHASE2
NCT05886634	ACTIVE_NOT_RECRUITING	Dedifferentiated Liposarcoma; Soft Tissue Sarcoma; Sarcoma,Soft Tissue; Sarcoma; Recurrent Dedifferentiated Liposarcoma; Unresectable Dedifferentiated Liposarcoma; Metastatic Dedifferentiated Liposarcoma	Memorial Sloan Kettering Cancer Center	2023-05-23	PHASE2
NCT03821246	RECRUITING	Prostate Adenocarcinoma; Prostate Cancer; Localized Prostate Cancer	David Oh	2019-10-30	PHASE2
NCT06048484	RECRUITING	Pancreatic Ductal Adenocarcinoma	Gulam Manji	2024-05-10	PHASE2
NCT05915442	RECRUITING	Oligometastatic Prostate Cancer	Catherine Spina	2023-07-01	PHASE2

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Etrumadenant (AB928) Adenosine Receptor antagonist

Chemical Structure

Molecular Weight: 426.47