CAS No. 251945-92-3

Batch: Purity:99.62
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Derenofylline (SLV320) Chemical Structure
Chemical Structure
Check the Derenofylline (SLV320) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexan-1-ol
CAS Number 251945-92-3
Molecular Formula

C18H20N4O
Molecular Weight (MW) 308.38
SMILES C1CC(CCC1NC2=NC(=NC3=C2C=CN3)C4=CC=CC=C4)O
InChIKey RBZNJGHIKXAKQE-UHFFFAOYSA-N

Ordering Information

Biological Activity

Derenofylline (SLV320) is a selective adenosine A1 receptor antagonist. By selectively targeting adenosine A1 receptors, it blocks receptor-mediated Gi protein signaling pathways and influences downstream intracellular cyclic AMP modulation. This selective inhibition regulates renal vascular tone and tubuloglomerular feedback mechanisms, contributing to enhanced sodium excretion and renal hemodynamic regulation without impairing glomerular filtration. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 62 mg/mL (201.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 16 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.