CAS No. 541-22-0
Batch:
Purity:100.00
Chemical Structure
Check the
Decamethonium Bromide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 541-22-0 | |
|---|---|---|
| Molecular Formula |
C16H38N2.2Br |
|
| Molecular Weight (MW) | 418.29 | |
| SMILES | C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C.[Br-].[Br-] |
Biological Activity
Decamethonium Bromide is a nicotinic acetylcholine receptor (nAChR) partial agonist and depolarizing neuromuscular blocking agent. It acts by binding to muscle-type nAChRs at the neuromuscular junction, inducing persistent depolarization of the motor endplate. This prolonged activation leads to receptor desensitization and inactivation of voltage-gated sodium channels, thereby inhibiting neuromuscular transmission and causing flaccid muscle paralysis.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 84 mg/mL |
| DMSO |
34 mg/mL
(81.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
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Note: Technical data last updated: Sep 1, 2026.