Ciforadenant (CPI-444)

Catalog No.S6646 Batch:S664601

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Technical Data

Formula

C20H21N7O3
Molecular Weight 407.43 CAS No. 1202402-40-1
Solubility (25°C)* In vitro DMSO 81 mg/mL (198.8 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Ciforadenant (CPI-444, V81444) is a potent and selective Adenosine A2A receptor antagonist. It binds to A2A receptors with a Ki of 3.54 nmol/L and demonstrates a greater than 50-fold selectivity for the A2A receptor over other adenosine receptor subtypes.
Targets
A2AR [1]
3.54 nM(Ki)
In vitro

CPI-444 restores T-cell activation in vitro[1].
In vivo

CPI-444 treatment resulted in a similar inhibition of tumor growth in the B16F10 melanoma (100 mg/kg) and RENCA renal cell cancer syngeneic models (10 mg/kg). It enhances T-cell activation in both the periphery and tumor microenvironment[1].

Protocol (from reference)

Animal Study:

[1]
  • Animal Models

    C57BL/6 mice engrafted MC38 cells

  • Dosages

    1, 10, or 100 mg/kg

  • Administration

    oral gavage

Selleck's Ciforadenant (CPI-444) has been cited by 1 publication

Additive effect of CD73 inhibitor in colorectal cancer treatment with CDK4/6 inhibitor through regulation of PD-L1 [ Cell Mol Gastroenterol Hepatol, 2022, S2352-345X(22)00163-1] PubMed: 35843546

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.