CAS No. 1066-17-7
| IUPAC Name | N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-5-methylheptanamide | |
|---|---|---|
| CAS Number | 1066-17-7 | |
| Molecular Formula |
C52H98N16O13 |
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| Molecular Weight (MW) | 1155.43 | |
| SMILES | NA | |
| InChIKey | YKQOSKADJPQZHB-QNPLFGSASA-N |
Colistin (Polymyxin E) is a cyclic lipopeptide antibiotic that targets Gram-negative bacterial membranes by binding lipopolysaccharide (LPS). Interaction with LPS destabilizes the bacterial cell envelope and disrupts membrane integrity, promoting cytoplasmic membrane permeabilization. This structural disruption leads to solute leakage, loss of cellular homeostasis, and rapid bactericidal cell lysis across susceptible Gram-negative bacterial species. [1][2]
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Concentration
Volume
Mass
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| Solvent | Solubility & Note |
|---|---|
| Water | 100 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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