CAS No. 469-83-0
Batch:
Purity:99.93
Chemical Structure
Check the
Cafestol
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (1S,4S,12S,13R,16R,17R)-17-(hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.01,13.04,12.05,9]nonadeca-5(9),6-dien-17-ol | |
|---|---|---|
| CAS Number | 469-83-0 | |
| Molecular Formula |
C20H28O3 |
|
| Molecular Weight (MW) | 316.43 | |
| SMILES | CC12CCC3=C(C1CCC45C2CCC(C4)C(C5)(CO)O)C=CO3 | |
| InChIKey | DNJVYWXIDISQRD-HWUKTEKMSA-N |
Cafestol is a natural coffee-derived diterpene that acts as a bioactive modulator of cellular survival and inflammatory signaling. It inhibits the PI3K/AKT pathway, regulating key inflammatory mediators to attenuate inflammation. In leukemia HL60 cells, cafestol reduces the production of reactive oxygen species (ROS) and triggers apoptotic cell death. These downstream effects contribute to suppressed inflammatory responses and reduced cancer cell survival. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
63 mg/mL
(199.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 63 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.