CAS No. 444805-28-1
Batch:
Purity:99.72
Chemical Structure
Check the
Brincidofovir
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethyl-(3-hexadecoxypropoxy)phosphinic acid | |
|---|---|---|
| CAS Number | 444805-28-1 | |
| Molecular Formula |
C27H52N3O7P |
|
| Molecular Weight (MW) | 561.69 | |
| InChIKey | WXJFKKQWPMNTIM-VWLOTQADSA-N |
Brincidofovir is a lipid-conjugated prodrug of cidofovir that acts as a broad-spectrum antiviral agent targeting viral DNA polymerase. Interference with viral DNA synthesis disrupts viral genome replication and suppresses double-stranded DNA virus propagation in host cells. In vitro, this lipid conjugation enhances cellular uptake and provides potently increased antiviral activity against cytomegalovirus and herpesviruses compared to parent cidofovir. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| 0.1mNAOH | 10 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.