Home Metabolism Factor Xa inhibitor Asundexian

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Asundexian Factor Xa inhibitor

Cat.No.E1789

Asundexian (BAY 2433334) is an orally administered inhibitor of coagulation factor XIa (FXIa). It binds reversibly to the FXIa active site with high affinity, blocking its enzymatic function. In buffer systems, asundexian exhibits an IC50 of 1 nM against human FXIa.
Asundexian Factor Xa inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 592.93

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Chemical Information, Storage & Stability

Molecular Weight 592.93 Formula C26H21ClF4N6O4 Storage (From the date of receipt)
CAS No. 2064121-65-7 Download SDF Storage of Stock Solutions

Synonyms BAY-2433334 SMILES COC(C(C1=C(N2C=C(N=N2)C(F)(F)F)C=CC(Cl)=C1)=C3)=CN([C@@H](CC)C(NC4=CC(F)=C(C=C4)C(N)=O)=O)C3=O

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Mechanism of Action

In vivo
Asundexian displays potent anticoagulant activity in vitro in human and rabbit plasma and antithrombotic efficacy in vivo in a rabbit arterial thrombosis model.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-11-12)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05686070 COMPLETED
Prevention of Ischemic Stroke; Acute Non-cardioembolic Ischemic Stroke; High-risk Transient Ischemic Attack
Bayer
 2023-01-26 PHASE3
NCT05643573 TERMINATED
Prevention of Stroke or Systemic Embolism; Atrial Fibrillation
Bayer
 2022-12-05 PHASE3
NCT05419635 COMPLETED
Prevention of Thromboembolic Events; Atrial Fibrillation; Acute Myocardial Infarction; Non-cardioembolic Ischemic Stroke; Hepatic Impairment
Bayer
 2022-06-14 PHASE1

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