CAS No. 65-19-0
| IUPAC Name | methyl (1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate;hydrochloride | |
|---|---|---|
| CAS Number | 65-19-0 | |
| Molecular Formula |
C21H26N2O3.HCl |
|
| Molecular Weight (MW) | 390.9 | |
| InChIKey | PIPZGJSEDRMUAW-VJDCAHTMSA-N |
Yohimbine HCl is a selective pre-synaptic α2-adrenergic receptor antagonist. By blocking central α2-adrenergic receptors, it prevents negative feedback inhibition of norepinephrine release, thereby enhancing central sympathetic outflow and noradrenergic neuronal firing. This elevation in norepinephrine transmission leads to downstream physiological responses, including increased heart rate, elevated blood pressure, antidiuretic effects, and improved erectile function. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
16 mg/mL
(40.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
15 mg/mL
(38.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
16 mg/mL
(40.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
18 mg/mL
(46.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 4 mg/mL (超声加热五分钟) |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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