Tanshinone IIA

Catalog No.S2365 Synonyms: Tanshinone B

For research use only.

Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor.

Tanshinone IIA Chemical Structure

CAS No. 568-72-9

Selleck's Tanshinone IIA has been cited by 14 publications

Purity & Quality Control

Choose Selective Lipase Inhibitors

Biological Activity

Description Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor.
Targets
monoacylglycerol lipase [4]
In vitro

Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases. Tanshinone IIA protects cardiac myocytes against oxidative stress-induced apoptosis. The in vivo protection is mediated by increased scavenging of oxygen free radicals, prevention of lipid peroxidation and upregulation of the Bcl-2/Bax ratio. [1] Recently, tanshinone IIA was demonstrated to induce cell death and apoptosis in a variety of tumors. [2]

In vivo LD50: Rats 25g/kg (i.g.) [3]

Protocol (from reference)

Solubility (25°C)

In vitro

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
5% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.

0.2mg/mL

Chemical Information

Molecular Weight 294.34
Formula

C19H18O3

CAS No. 568-72-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C

In vivo Formulation Calculator (Clear solution)

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% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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