Sinomenine

Catalog No.S2359 Synonyms: Cucoline, Kukoline

For research use only.

Sinomenine (Cucoline, Kukoline), a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis.

Sinomenine Chemical Structure

CAS No. 115-53-7

Selleck's Sinomenine has been cited by 11 Publications

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Biological Activity

Description Sinomenine (Cucoline, Kukoline), a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis.
In vitro

Sinomenine, a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis. [1] However its analgesic action against other kinds of pain is limited. Sinomenine is a morphinan derivative, related to opioids such as levorphanol and the non-opioid cough suppressant dextromethorphan. [2] Its anti-rheumatic effects are thought to be primarily mediated via release of histamine, but other effects such as inhibition of prostaglandin, leukotriene and nitric oxide synthesis may also be involved. [3]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 329.39
Formula

C19H23NO4

CAS No. 115-53-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN1CCC23CC(=O)C(=CC2C1CC4=C3C(=C(C=C4)OC)O)OC

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