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Silymarin Antioxidant chemical

Cat.No.S2358

Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer.
Silymarin Antioxidant chemical Chemical Structure

Chemical Structure

Molecular Weight: 482.44

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Chemical Information, Storage & Stability

Molecular Weight 482.44 Formula

C25H22O10

 Storage (From the date of receipt) 3 years -20°C powder (seal)
CAS No. 65666-07-1 Download SDF Storage of Stock Solutions Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.
Synonyms Silybin B SMILES COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O

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Mechanism of Action

In vitro

Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer. The mechanisms of action of this compound involve different biochemical events, such as the stimulation of the synthetic rate of ribosomal RNA (rRNA) species through stimulation of polymerase I and rRNA transcription, protecting the cell membrane from radical-induced damage and blockage of the uptake of toxins such as alpha-amanitin. This chemical can also provide substantial protection against different stages of UVB-induced carcinogenesis, possibly via its strong antioxidant properties.

In vivo

LD50: Mice 391.4mg/kg (i.v.); Rats 370.1mg/kg (i.v.); Rabbits 142.3mg/kg (i.v.)

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-02-13)

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