Silymarin

For research use only.

Catalog No.S2358 Synonyms: Silybin B

2 publications

Silymarin Chemical Structure

CAS No. 65666-07-1

Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer.

Selleck's Silymarin has been cited by 2 publications

1 Customer Review

  • Silymarin improved HFD-induced hepatic injury. Mice were fed with NCD or HFD for 14 weeks, then treated with silymarin for 3 weeks, followed by 12 h fasting. (a) ALT and AST levels in serum were determined. (b) Hematoxylin and eosin staining of liver (400×) was showed. Values are means ± SD (n = 8). *p < 0.05 and **p < 0.01 compared to HFD group.

    Pharm Biol, 2016, 8:1-6.. Silymarin purchased from Selleck.

Purity & Quality Control

Biological Activity

Description Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer.
In vitro

Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer. [1] The mechanisms of action of silymarin involve different biochemical events, such as the stimulation of the synthetic rate of ribosomal RNA (rRNA) species through stimulation of polymerase I and rRNA transcription, protecting the cell membrane from radical-induced damage and blockage of the uptake of toxins such as alpha-amanitin. [2] Silymarin can also provide substantial protection against different stages of UVB-induced carcinogenesis, possibly via its strong antioxidant properties. sup>[3]

In vivo LD50: Mice 391.4mg/kg (i.v.); Rats 370.1mg/kg (i.v.); Rabbits 142.3mg/kg (i.v.) sup>[4]

Protocol

Solubility (25°C)

In vitro DMSO 96 mg/mL warmed (198.98 mM)
Ethanol 1 mg/mL (2.07 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 482.44
Formula

C25H22O10

CAS No. 65666-07-1
Storage powder
in solvent
Synonyms Silybin B
Smiles COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04434404 Completed Drug: L-Carnitine 500Mg Oral Tablet Breast Cancer Horus University September 10 2018 Phase 4
NCT03216668 Unknown status Drug: TONKA|Drug: LEGALON Liver Function Failure Nhat Nhat Pharmaceutical Company June 15 2017 Phase 3
NCT02006498 Completed Drug: Sillymarin|Drug: Placebo Non-alcoholic Fatty Liver Disease University of Malaya|Rottapharm June 2012 Phase 2
NCT01018615 Completed Drug: silymarin|Dietary Supplement: green tea extract (EGCG) Chronic Hepatitis C|Oxidative Stress University of North Carolina Chapel Hill|National Center for Complementary and Integrative Health (NCCIH)|National Institutes of Health (NIH) November 2009 Phase 1
NCT00055718 Completed Dietary Supplement: silymarin Drug/Agent Toxicity by Tissue/Organ|Leukemia Herbert Irving Comprehensive Cancer Center|National Cancer Institute (NCI) November 2001 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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