Silymarin

Catalog No.S2358 Synonyms: Silybin B

For research use only.

Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer.

Silymarin Chemical Structure

CAS No. 65666-07-1

Selleck's Silymarin has been cited by 2 Publications

1 Customer Review

Purity & Quality Control

Choose Selective Antioxidant Inhibitors

Biological Activity

Description Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer.
In vitro

Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer. [1] The mechanisms of action of silymarin involve different biochemical events, such as the stimulation of the synthetic rate of ribosomal RNA (rRNA) species through stimulation of polymerase I and rRNA transcription, protecting the cell membrane from radical-induced damage and blockage of the uptake of toxins such as alpha-amanitin. [2] Silymarin can also provide substantial protection against different stages of UVB-induced carcinogenesis, possibly via its strong antioxidant properties. sup>[3]

In vivo LD50: Mice 391.4mg/kg (i.v.); Rats 370.1mg/kg (i.v.); Rabbits 142.3mg/kg (i.v.) sup>[4]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 482.44
Formula

C25H22O10

CAS No. 65666-07-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05099601 Not yet recruiting Combination Product: Silymarin|Procedure: Microneedling Melasma Assiut University May 2022 Phase 4
NCT04434404 Completed Drug: L-Carnitine 500Mg Oral Tablet Breast Cancer Horus University September 10 2018 Phase 4
NCT03216668 Unknown status Drug: TONKA|Drug: LEGALON Liver Function Failure Nhat Nhat Pharmaceutical Company June 15 2017 Phase 3
NCT02006498 Completed Drug: Sillymarin|Drug: Placebo Non-alcoholic Fatty Liver Disease University of Malaya|Rottapharm June 2012 Phase 2
NCT01018615 Completed Drug: silymarin|Dietary Supplement: green tea extract (EGCG) Chronic Hepatitis C|Oxidative Stress University of North Carolina Chapel Hill|National Center for Complementary and Integrative Health (NCCIH)|National Institutes of Health (NIH) November 2009 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Silymarin | Silymarin supplier | purchase Silymarin | Silymarin cost | Silymarin manufacturer | order Silymarin | Silymarin distributor