Paeonol

Catalog No.S2339 Synonyms: Peonol

For research use only.

Paeonol (Peonol), a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum, inhibits MAO with an IC50 of about 50 μM.

Paeonol Chemical Structure

CAS No. 552-41-0

Selleck's Paeonol has been cited by 1 Publication

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Biological Activity

Description Paeonol (Peonol), a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum, inhibits MAO with an IC50 of about 50 μM.
Targets
MAO-B [1] MAO-A [1]
42.5 μM 54.6 μM
In vitro

Paeonol (Peonol) is a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum. It has demonstrated significant MAOI activity. MAO-A and MAO-B inhibiting effects with IC50 values of 54.6 μM and 42.5 μM respectively. [1] Paeonol shows antimutagenic, anti-inflammatory and analgesic effects. [2] Paeonol also inhibits anaphylactic reaction by regulating histamine and TNF-α. [3]

In vivo LD50: Mice 608-899mg/kg (i.p.). [4]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 166.17
Formula

C9H10O3

CAS No. 552-41-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(=O)C1=C(C=C(C=C1)OC)O

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