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Technical Data
| Formula | C8H11N5O3 |
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| Molecular Weight | 225.2 | CAS No. | 59277-89-3 | |
| Solubility (25°C)* | In vitro | DMSO | 45 mg/mL (199.82 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Acyclovir (Aciclovir) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells. | |
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| In vitro | Acyclovir sensitivity of herpes simplex virus isolates is determined in a plaque-reduction assay in Vero cells. IC50 Values are consistently 2-3 fold lower in B2 compared with the H strain of Vero cells. HSV Type 2 strains are 2-10-fold less sensitive than Type 1 strains[2]. |
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| In vivo | low-dose oral acyclovir may be effective in the prevention of HSV infection during OKT3 treatment of seropositive patients. Continuation of acyclovir prophylaxis for two to four weeks following the conclusion of OKT3 therapy may prevent occurrence of delayed infections[3]. |
Protocol (from reference)
References
Customer Product Validation
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Data from [Data independently produced by , , Oncol Rep, 2017, 37(4):2109-2120]
Selleck's Acyclovir (Aciclovir) has been cited by 16 publications
| Topical phenylbutyrate antagonizes NF-κB signaling and resolves corneal inflammation [ iScience, 2022, 25(12):105682] | PubMed: 36536680 |
| Prevention of Herpesviridae Infections by Cationic PEGylated Carbosilane Dendrimers [ Pharmaceutics, 2022, 14(3)536] | PubMed: 35335912 |
| Safety, efficacy and delivery of multiple nucleoside analogs via drug encapsulated carbon (DECON) based sustained drug release platform [ Eur J Pharm Biopharm, 2022, S0939-6411(22)00047-9] | PubMed: 35314347 |
| Harringtonine Inhibits Herpes Simplex Virus Type 1 Infection by Reducing Herpes Virus Entry Mediator Expression [ Front Microbiol, 2021, 12:722748] | PubMed: 34531841 |
| 6-Thioguanine Inhibits Herpes Simplex Virus 1 Infection of Eyes [ Microbiol Spectr, 2021, 9(3):e0064621] | PubMed: 34730435 |
| A natural product, (S)-10-Hydroxycamptothecin inhibits pseudorabies virus proliferation through DNA damage dependent antiviral innate immunity [ Vet Microbiol, 2021, 265:109313] | PubMed: 34968801 |
| Pharmaceutically Acceptable Carboxylic Acid-Terminated Polymers Show Activity and Selectivity against HSV-1 and HSV-2 and Synergy with Antiviral Drugs [ ACS Infect Dis, 2020, 6(11):2926-2937] | PubMed: 33078609 |
| In Vitro and In Vivo Activity, Tolerability and Mechanism of Action of BX795 as an Antiviral against Herpes Simplex Virus-2 Genital Infection [ Antimicrob Agents Chemother, 2020, AAC.00245-20] | PubMed: 32601167 |
| Anti-HSV-1 effect of dihydromyricetin from Ampelopsis grossedentata via the TLR9-dependent anti-inflammatory pathway [ J Glob Antimicrob Resist, 2020, S2213-7165(20)30264-2] | PubMed: 33161114 |
| Standalone or combinatorial phenylbutyrate therapy shows excellent antiviral activity and mimics CREB3 silencing [ Sci Adv, 2020, 6(49)eabd9443] | PubMed: 33277262 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.