CAS No. 2457-80-9

Batch: Purity:99.03
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5'-Deoxy-5'-(methylthio)adenosine Chemical Structure
Chemical Structure
Check the 5'-Deoxy-5'-(methylthio)adenosine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol
CAS Number 2457-80-9
Molecular Formula

C11H15N5O3S
Molecular Weight (MW) 297.34
InChIKey WUUGFSXJNOTRMR-IOSLPCCCSA-N

Ordering Information

Biological Activity

5'-Deoxy-5'-(methylthio)adenosine (Methylthioadenosine) is a naturally occurring sulfur-containing nucleoside that acts as an agonist for adenosine receptors, including A1, A2A, A2B, and A3 receptors. It regulates polyamine biosynthesis and transmethylation reactions, impacting downstream cell signaling cascades such as the MAPK and NF-kB pathways. Through these targeted mechanisms, methylthioadenosine modulates cellular responses by inhibiting cell proliferation, suppressing inflammatory signaling, and promoting apoptosis in diverse cell types. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 59 mg/mL (198.42 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 6 mg/mL
Ethanol 3 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.