Clioquinol

Catalog No.S4601 Batch:S460101

Technical Data

Formula	C₉H₅ClINO
Molecular Weight	305.50	CAS No.	130-26-7
Solubility (25°C)*	In vitro	DMSO	61 mg/mL (199.67 mM)
		Ethanol	1 mg/mL (3.27 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	Clioquinol is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities.

Protocol (from reference)

Cell Assay:^{^[2]}	Cell lines DU 145 cells Concentrations 10 μM Incubation Time 2 h Method DU 145 cells are plated in a 12-well plate. After incubation for 24 h, the cells are treated with 10 μM clioquinol and 50 μM ZnCl₂ for 2 h. AO is then added to each well (at a final concentration of 2.5 μg/ml). After 30 min of incubation with AO, cells are washed twice with HBSS and examined with a fluorescence microscope.
Animal Study:^{^[1]}	Animal Models Golden Syrian Hamsters Dosages 7.5 mg/kg Administration s.c.

Cell Assay:^{^[2]}

Cell lines
DU 145 cells
Concentrations
10 μM
Incubation Time
2 h
Method
DU 145 cells are plated in a 12-well plate. After incubation for 24 h, the cells are treated with 10 μM clioquinol and 50 μM ZnCl₂ for 2 h. AO is then added to each well (at a final concentration of 2.5 μg/ml). After 30 min of incubation with AO, cells are washed twice with HBSS and examined with a fluorescence microscope.

Animal Study:^{^[1]}

Animal Models
Golden Syrian Hamsters
Dosages
7.5 mg/kg
Administration
s.c.

References

Selleck's Clioquinol has been cited by 3 publications

Induction of IFIT1/IFIT3 and inhibition of Bcl-2 orchestrate the treatment of myeloma and leukemia via pyroptosis [ Cancer Lett, 2024, 588:216797]	PubMed: 38462032
Elesclomol induces copper-dependent ferroptosis in colorectal cancer cells via degradation of ATP7A [ Mol Oncol, 2021, 10.1002/1878-0261.13079]	PubMed: 34390123
Controlling distinct signaling states in cultured cancer cells provides a new platform for drug discovery [ FASEB J, 2019, 10.1096/fj.201802603RR]	PubMed: 31145643

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.