CAS No. 130-26-7
Batch:
Purity:97
Chemical Structure
Check the
Clioquinol
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-chloro-7-iodoquinolin-8-ol | |
|---|---|---|
| CAS Number | 130-26-7 | |
| Molecular Formula |
C9H5ClINO |
|
| Molecular Weight (MW) | 305.50 | |
| SMILES | C1=CC2=C(C(=C(C=C2Cl)I)O)N=C1 | |
| InChIKey | QCDFBFJGMNKBDO-UHFFFAOYSA-N |
Clioquinol is an orally bioavailable, lipophilic, copper-binding halogenated 8-hydroxyquinoline with antifungal, antiparasitic, and potential antitumor activities. It acts as a metal ionophore to shuttle copper into cells, inhibiting proteasome activity and triggering intracellular reactive oxygen species generation. This pathway suppression leads to the induction of caspase-dependent apoptosis and growth inhibition in hematological and solid cancer models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
61 mg/mL
(199.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.