CAS No. 490-78-8

Batch: Purity:99.78
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2',5'-Dihydroxyacetophenone Chemical Structure
Chemical Structure
Check the 2',5'-Dihydroxyacetophenone product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-(2,5-dihydroxyphenyl)ethanone
CAS Number 490-78-8
Molecular Formula

C8H8O3
Molecular Weight (MW) 152.15
SMILES CC(=O)C1=C(C=CC(=C1)O)O
InChIKey WLDWSGZHNBANIO-UHFFFAOYSA-N

Ordering Information

Biological Activity

2',5'-Dihydroxyacetophenone is a dihydroxyacetophenone derivative that acts as an anti-inflammatory agent by suppressing inducible nitric oxide synthase (iNOS) expression and inhibiting nitric oxide (NO) production. Furthermore, 2',5'-dihydroxyacetophenone significantly decreases the secretion of pro-inflammatory cytokines, including TNF-α and IL-6, by blocking upstream ERK1/2 and NF-κB signaling cascades to suppress downstream inflammatory responses. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 30 mg/mL (197.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.