Home DNA Damage/DNA Repair HDAC inhibitor 1-Naphthohydroxamic acid

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1-Naphthohydroxamic acid HDAC inhibitor

Cat.No.E6577

1-Naphthohydroxamic acid (Compound 2) demonstrates potent and selective inhibition of HDAC8 (IC50 = 14 μM), exhibiting significantly greater selectivity for HDAC8 compared to class I HDAC1 and class II HDAC6 (IC50 >100 μM). This compound does not elevate global histone H4 acetylation levels nor decrease total intracellular HDAC activity. Additionally, 1-naphthohydroxamic acid has been shown to promote tubulin acetylation.
1-Naphthohydroxamic acid HDAC inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 187.19

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Chemical Information, Storage & Stability

Molecular Weight 187.19 Formula

C11H9NO2

 Storage (From the date of receipt)
CAS No. 6953-61-3 Download SDF Storage of Stock Solutions

Mechanism of Action

In vivo
Dose-limiting toxicities (DLTs) of 1-Naphthohydroxamic acid (compound 2; 0-40 mg/kg; intraperitoneal injection; daily; for 10 day; NMRI Foxn1 nude mice) include weight loss and signs of liver toxicity, as evidenced by elevated plasma liver enzymes and detection of necrotic areas on histological liver examination. This compound has the maximum tolerable doses at 50?mg/kg per day. At these concentrations, neither body weight nor blood parameters are critically changed. Pharmacokinetic studies after intraperitoneal administration of the inhibitors identified the half-life of this chemical to be ~15?min, with a plasma peak concentration of ~30?μM.
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