Home DNA Damage/DNA Repair HDAC inhibitor 1-Naphthohydroxamic acid

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1-Naphthohydroxamic acid HDAC inhibitor

1-Naphthohydroxamic acid (Compound 2) demonstrates potent and selective inhibition of HDAC8 (IC50 = 14 μM), exhibiting significantly greater selectivity for HDAC8 compared to class I HDAC1 and class II HDAC6 (IC50 >100 μM). This compound does not elevate global histone H4 acetylation levels nor decrease total intracellular HDAC activity. Additionally, 1-naphthohydroxamic acid has been shown to promote tubulin acetylation.

1-Naphthohydroxamic acid HDAC inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 187.19

Purity & Quality Control

Related Products

Signaling Pathway

HDAC Signaling Pathways

HDAC Signaling Pathway

Mechanism of Action

In Vivo
In vivo Dose-limiting toxicities (DLTs) of 1-Naphthohydroxamic acid (compound 2; 0-40 mg/kg; intraperitoneal injection; daily; for 10 day; NMRI Foxn1 nude mice) include weight loss and signs of liver toxicity, as evidenced by elevated plasma liver enzymes and detection of necrotic areas on histological liver examination. This compound has the maximum tolerable doses at 50?mg/kg per day. At these concentrations, neither body weight nor blood parameters are critically changed. Pharmacokinetic studies after intraperitoneal administration of the inhibitors identified the half-life of this chemical to be ~15?min, with a plasma peak concentration of ~30?μM.

References
  • https://www.ncbi.nlm.nih.gov/17346959
  • https://www.ncbi.nlm.nih.gov/19118036

Chemical Information

Molecular Weight 187.19 Formula

C11H9NO2
CAS No. 6953-61-3 SDF Download SDF
Smiles O=C(C1=C2C=CC=CC2=CC=C1)NO

Storage and Stability

Storage (From the date of receipt)

In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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