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HIV Protease Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S1185 Ritonavir Ritonavir is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. This compound induces apoptosis.
Nature, 2025, 10.1038/s41586-025-09755-9
Vet Parasitol, 2025, 337:110471
Cell Chem Biol, 2024, S2451-9456(24)00396-9
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S1380 Lopinavir (ABT-378) Lopinavir (ABT-378) is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay.
Viruses, 2025, 1391
J Microbiol Biotechnol, 2025, 35:e2411063
Nat Commun, 2023, 14(1):5034
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S7381 Pepstatin A Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.
Signal Transduct Target Ther, 2025, 10(1):412
Nat Commun, 2025, 16(1):4069
Autophagy, 2025, 21(11):2473-2496
S1457 Atazanavir (BMS-232632) Sulfate Atazanavir Sulfate (BMS-232632-05, Reyataz) is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.
Science Advances, 2025, eads1875
bioRxiv, 2024, 2024.05.10.593637
bioRxiv, 2023, nan
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S4282 Nelfinavir Mesylate Nelfinavir Mesylate is a potent HIV protease inhibitor with Ki of 2 nM.
Biochem Biophys Rep, 2025, 42:101987
Int J Mol Sci, 2023, 24(7)6062
Int. J. Mol. Sci, 2023, 10.3390/ijms24076062
S5250 Darunavir Darunavir (TMC114,DRV) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.
Front Cell Infect Microbiol, 2024, 14:1334126
International Journal of Molecular Sciences, 2024, 2220
Frontiers in Microbiology, 2024, 1384009
S4662 Atazanavir Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. This compound is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.
Anticancer Research, July 15, 2019, 3757-3765
Journal of Virology, April 17, 2019, e00077-19
Int J Mol Sci, 2022, 23(23)15380
S1620 Darunavir Ethanolate Darunavir Ethanolate (TMC-114, UIC 94017) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.
mBio, November 06, 2018, e01423-18
Antimicrobial Agents and Chemotherapy, April 24, 2017, e01776-16
J Virol, 2022, JVI0173021
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S9567 Indinavir Sulfate Indinavir sulfate (Crixivan, L-735524, MK-639) is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.
Antimicrob Agents Chemother, 2023, 67(7):e0046223
J Cell Biochem, 2022, 10.1002/jcb.30213
Mol Metab, 2020, 29;101027
S2319 Limonin Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.
Int J Biol Sci, 2019, 15(11):2497-2508
Biomed Pharmacother, 2019, 118:109366
Food Chem Toxicol, 2019, 125:621-628
S1639 Amprenavir (VX-478) Amprenavir (VX-478, 141W94, KVX-478) is a potent PXR-selective agonist and an HIV protease inhibitor, used to treat HIV.
Nature Communications, August 18, 2023, 5034
Nat Commun, 2023, 14(1):5034
Sci Rep, 2021, 11(1):19443
S6625 Temsavir (BMS-626529) Temsavir (BMS-626529) is a novel small-molecule HIV-1 attachment inhibitor active against both CCR5- and CXCR4-tropic viruses.
J Virol, 2023, 97(10):e0115423
Journal of Virology, 2023, e0115423
Journal of Chemical Information and Modeling, 2019, 3853-3867
S6929 Dextran sulfate sodium (DSS) Dextran sulfate sodium (DSS) is a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro that inhibits virus adsorption to the host cells, and this compound can be used to induce animal models of Enteritis, Ulcerative Colitis.
Frontiers in Immunology, October 01, 2025, 1610540
Acta Microbiologica et Immunologica Hungarica, April 16, 2026, 030.2026.02853
S6581 Fosamprenavir calcium salt Fosamprenavir(GW433908G) is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It is used for the treatment of HIV-1 infections.
Antimicrobial Agents and Chemotherapy, 2020, e00872-20
Antimicrob Agents Chemother, 2020, AAC.00872-20
PhD thesis, University of Liverpool, 2018, nan
S9010 Bevirimat Bevirimat (MPC-4326, PA-457, YK-FH312), the prototype Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor, is highly potent in cell culture and efficacious in HIV-1 infected patients.
bioRxiv, July 16, 2025, nan
S3287 Rosamultin Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. This compound has protective effects on H2O2-induced oxidative damage and apoptosis.
S9625 Saquinavir (Ro 31-8959) Saquinavir (Ro 31-8959,SAQ) is a potent and selective inhibitor of HIV proteinase with a mean IC50 of 2.7 nM in JM cells.
E0943 NBD-556 NBD-556 is a novel human immunodeficiency virus type 1 (HIV-1) entry inhibitor that block the gp120-CD4 interaction.
S9633 GS-6207 (Lenacapavir) GS-6207 (Lenacapavir) is a HIV-1 capsid inhibitor. It shows anti-HIV activity with an EC50 of 0.1 nM in MT-4 cells.
E4466 Saquinavir Mesylate Saquinavir mesylate (Ro 31-8959/003) is a potent inhibitor of HIV Protease used in antiretroviral therapy. It blocks proteolysis of polyproteins containing either wild-type or single-chain dimer retroviral proteinase (PR).
E1243 Azvudine Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).
S1030 Panobinostat (LBH589) Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. It induces autophagy and apoptosis, and effectively disrupts HIV latency in vivo. Phase 3.
J Cell Mol Med, 2026, 30(4):e71053
Hematol Oncol, 2026, 44(2):e70175
Cancer Cell, 2025, 43(4):776-796.e14
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S6999 Chloroquine Chloroquine is an antimalarial drug and autophagy/lysosome inhibitor. Chloroquine also suppresses Toll-like receptor-9 (TLR9) protein expression. Chloroquine is highly effective agianst SARS-CoV-2 (COVID-19) infection with EC50 of 1.13 μM in Vero E6 cells. Chloroquine has anti-HIV-1 activity.
Adv Sci (Weinh), 2026, 13(19):e02610
Signal Transduct Target Ther, 2025, 10(1):26
Cell Discov, 2025, 11(1):15
S3494 Vicriviroc maleate Vicriviroc maleate(SCH-417690 maleate,SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells.
Breast Cancer Res, 2021, 23(1):11