Amino acid transporter

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S4218 Amoxapine <1 mg/mL 3 mg/mL <1 mg/mL
S8667 JPH203 <1 mg/mL 0.01 mg/mL <1 mg/mL
S8219 Bitopertin <1 mg/mL 100 mg/mL 100 mg/mL
S4702 Sarcosine 17 mg/mL <1 mg/mL <1 mg/mL
Catalog No. Information Product Use Citations Product Validations
S4218

Amoxapine

Amoxapine is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants, amoxapine inhibits GLYT2a transport activity with IC50 of 92 μM.
S8667

JPH203

JPH203, a selective L-type amino acid transporter 1 inhibitor, shows a dramatic inhibition of leucine uptake (IC50=0.06 µM) and cell growth (IC50=4.1 µM) in human colon cancer cells (HT-29), human oral cancer cells (YD-38) and leukemic cells.
S8219

Bitopertin

Bitopertin (RG1678,RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells.
S4702

Sarcosine

Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
Tags: Amino acid transporter inhibitors | Amino acid transporter Inhibition