Amino acid transporter

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Amino acid transporter Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S4218 Amoxapine Amoxapine (CL 67772) is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants, amoxapine inhibits GLYT2a transport activity with IC50 of 92 μM.
S4702 Sarcosine Sarcosine (N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
S6670 GPNA (L-γ-Glutamyl-p-nitroanilide) GPNA (L-γ-Glutamyl-p-nitroanilide) is a potent and selective inhibitor of the glutamine (Gln) transporter ASCT2(SLC1A5) with Ki of 55 µM.
S6894 BCH BCH (2-Aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, LAT1-IN-1) is a selective and competitive inhibitor of system L amino acid transporter 1 (LAT1). BCH (LAT1-IN-1) induces apoptosis in cancer cells.
EMBO Rep, 2021, e51436
S8219 Bitopertin Bitopertin (RG1678,RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells.
Mol Ther, 2020, 6;28(5):1339-1358
S8667 Nanvuranlat (JPH203) Nanvuranlat (JPH203, KYT-0353, JPH-203SBECD), a selective L-type amino acid transporter 1 inhibitor, shows a dramatic inhibition of leucine uptake (IC50=0.06 µM) and cell growth (IC50=4.1 µM) in human colon cancer cells (HT-29), human oral cancer cells (YD-38) and leukemic cells.
Nature, 2021, 10.1038/s41586-021-04244-1
Immunity, 2021, 54(11):2514-2530.e7
Sci Immunol, 2021, 6(60)eabg0791
S8818 V-9302 V-9302 is a competitive small molecule antagonist of transmembrane glutamine flux, that selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) with an IC50 value of 9.6 μM for inhibition of glutamine uptake in HEK-293 cells. V-9302 blocks Sodium-neutral AA transporter 2 (SNAT2, SLC38A2) and the large neutral AA transporter 1 (LAT1, SLC7A5) as observed in 143B osteosarcoma cells, HCC1806 breast cancer cells and Xenopus laevis oocytes.
Br J Cancer, 2021, 10.1038/s41416-021-01636-y
Mol Oncol, 2021, 10.1002/1878-0261.12999
Mol Oncol, 2021, 10.1002/1878-0261.12999
S4218 Amoxapine Amoxapine (CL 67772) is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants, amoxapine inhibits GLYT2a transport activity with IC50 of 92 μM.
S4702 Sarcosine Sarcosine (N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
S6670 GPNA (L-γ-Glutamyl-p-nitroanilide) GPNA (L-γ-Glutamyl-p-nitroanilide) is a potent and selective inhibitor of the glutamine (Gln) transporter ASCT2(SLC1A5) with Ki of 55 µM.
S6894 BCH BCH (2-Aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, LAT1-IN-1) is a selective and competitive inhibitor of system L amino acid transporter 1 (LAT1). BCH (LAT1-IN-1) induces apoptosis in cancer cells.
EMBO Rep, 2021, e51436
S8219 Bitopertin Bitopertin (RG1678,RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells.
Mol Ther, 2020, 6;28(5):1339-1358
S8667 Nanvuranlat (JPH203) Nanvuranlat (JPH203, KYT-0353, JPH-203SBECD), a selective L-type amino acid transporter 1 inhibitor, shows a dramatic inhibition of leucine uptake (IC50=0.06 µM) and cell growth (IC50=4.1 µM) in human colon cancer cells (HT-29), human oral cancer cells (YD-38) and leukemic cells.
Nature, 2021, 10.1038/s41586-021-04244-1
Immunity, 2021, 54(11):2514-2530.e7
Sci Immunol, 2021, 6(60)eabg0791
S8818 V-9302 V-9302 is a competitive small molecule antagonist of transmembrane glutamine flux, that selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) with an IC50 value of 9.6 μM for inhibition of glutamine uptake in HEK-293 cells. V-9302 blocks Sodium-neutral AA transporter 2 (SNAT2, SLC38A2) and the large neutral AA transporter 1 (LAT1, SLC7A5) as observed in 143B osteosarcoma cells, HCC1806 breast cancer cells and Xenopus laevis oocytes.
Br J Cancer, 2021, 10.1038/s41416-021-01636-y
Mol Oncol, 2021, 10.1002/1878-0261.12999
Mol Oncol, 2021, 10.1002/1878-0261.12999
Tags: Amino acid transporter inhibitors | Amino acid transporter Inhibition