CMV Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S1878	Ganciclovir (BW 759)	Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.	Nat Commun, 2023, 14(1):441 Toxicol Appl Pharm, 2023, Volume 468, 116531 Toxicol Appl Pharm, 2023, Volume 468 116531
S5065	Ganciclovir sodium	Ganciclovir Sodium (RS-21592, Cytovene IV, BW 759, 2'-Nor-2'-deoxyguanosine) is the sodium salt form of ganciclovir, a synthetic, antiviral, purine nucleoside analog with antiviral activity, especially against cytomegalovirus (CMV).	Cell Prolif, 2023, 56(5):e13472 Cancer Lett, 2022, 524:131-143 JCI Insight, 2022, 7(14)e158207
S4050	Valganciclovir HCl	Valganciclovir HCl is a prodrug for ganciclovir with antiviral activity used to treat cytomegalovirus infections.	Sci Rep, 2025, 15(1):29020 bioRxiv, 2020, 2020.08.12.246389 Transl Res, 2016, 177:113-126
S8873	Letermovir (AIC246)	Letermovir (AIC246, MK-8228) is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors.	Heliyon, 2024, 10(15):e35331 Antiviral Res, 2021, 189:105062 bioRxiv, 2020, 2020.08.12.246389
S1876	Valaciclovir HCl	Valaciclovir HCl, an aciclovir prodrug, inhibits activity of virus DNA polymerase, used to treat infections caused by herpes simplex virus (HSV) and varicella zoster virus, and for prophylaxis against cytomegalovirus (CMV).	Sci Adv, 2020, 6(49)eabd9443
S0754	Bisindolylmaleimide IV	Bisindolylmaleimide IV (Arcyriarubin A, BIM IV, Compound 5/1a) is a potent inhibitor of protein kinase C (PKC) with IC50 of 0.55 μM. This compound also inhibits PKA with IC50 of 11.8μM. It is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with IC50 of 0.2 μM.	Elife, 2021, 10e68473
E1709	Fialuridine	Fialuridine(FIAU, DRG-0098, NSC 678514) is a nucleoside analog with antiviral activity. It blocks DNAsynthesis in human cytomegalovirus and hepatitis B, as well as herpes simplex.
S5009	Brivudine (BVDU)	Brivudine (BVDU) is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.
S1299	Floxuridine (FUDR)	Floxuridine (FUDR), a prodrug that is rapidly catabolized to 5-fluorouracil in vivo, is used to treat various cancers, particularly metastases to the liver. It inhibits Poly(ADP-Ribose) polymerase and induces DNA damage and apoptosis. This compound also has antiviral effects against HSV and CMV.	Toxicol Lett, 2025, 406:31-37 iScience, 2024, 27(10):110862 Cancer Cell, 2023, 41(5):933-949.e11
S7296	ML324	ML324 is a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM.	Mol Cell, 2025, 85(15):2973-2987.e6 Cancer Cell, 2023, 41(6):1118-1133.e12 EBioMedicine, 2023, 92:104602
S7889	Xanthohumol	Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. This compound inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 μM. It is also a potent antiviral agent against a series of DNA and RNA viruses. This chemical induces growth inhibition and apoptosis in cancer cells. Phase 1.	Oncotarget, 2025, 16:532-544 J Cell Sci, 2024, 137(20)jcs262162 Antiviral Res, 2022, 207:105416
S1516	Cidofovir	Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.	Oncol Lett, 2021, 21(4):280 Nat Biotechnol, 2019, 37(3):303-313 Antiviral Res, 2019, 162:178-185