Home Metabolism -Proteases Acyltransferase DGAT2 Inhibitors

DGAT2 Inhibitors

  • ACAT
  • ACAT1
  • ACAT2
  • DGAT
  • DGAT1
  • DGAT2
Catalog No. Product Name Information Selective / Pan IC50 / Ki
S6971 Ervogastat Ervogastat (PF-06865571, DGAT2i) is a potent diacylglycerol acyltransferase 2 (DGAT2) inhibitor that reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH). Pan
S9921 PF-06424439

PF-06424439 is a first orally bioavailable small-molecule inhibitor of DGAT2 with an IC50 of 14 nM.

 Pan DGAT2, IC50: 14 nM
s7889 Xanthohumol Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 μM. Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses. Xanthohumol induces growth inhibition and apoptosis in cancer cells. Phase 1. Pan DGAT2, IC50: 40 μM