Proteasome Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S2853 Carfilzomib (PR-171)

Carfilzomib (PR-171) is an irreversible proteasome inhibitor with IC50 of <5 nM, displayed preferential in vitro inhibitory potency against the ChT-L activity in the β5 subunit, but little or no effect on the PGPH and T-L activities.

Selective Proteasome, IC50: 5 nM
S2619 MG-132

MG-132 is an inhibitor of proteasome with IC50 of 100 nM, and also inhibits calpain with IC50 of 1.2 μM.

Selective Proteasome, IC50: 100 nM