Substance P

Inhibitory Selectivity

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Notes:
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Catalog No. Information Product Use Citations Product Validations
S1189

Aprepitant

Aprepitant is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM.

S4654New

Netupitant

Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity.

Catalog No. Information Product Use Citations Product Validations
S1189

Aprepitant

Aprepitant is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM.

2014, 60(5):985-94

2015, 10.1038/cdd.2015.128

2016, 9(438):ra74

S4654New

Netupitant

Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity.