Home Metabolism THR activator T3 (Triiodothyronine) For research use only.

T3 (Triiodothyronine)

Synonyms: Liothyronine, 3,3',5-Triiodo-L-thyronine

T3 (Triiodothyronine) is a thyroid hormone that affects various physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.This product is soluble but easy to precipitate after freezing in DMSO. 0.1 M NaOH is recommended as a stock solution.

T3 (Triiodothyronine) Chemical Structure

T3 (Triiodothyronine) Chemical Structure

CAS: 6893-02-3

Selleck's T3 (Triiodothyronine) has been cited by 5 publications

Purity & Quality Control

Batch: Purity: 99.35%
99.35

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Biological Activity

Description T3 (Triiodothyronine) is a thyroid hormone that affects various physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.This product is soluble but easy to precipitate after freezing in DMSO. 0.1 M NaOH is recommended as a stock solution.
In vitro
In vitro

Triiodothyronine is one ingredient supplemented in the medium for inducing brown adipocytes differentiation.[1]
Cell Research Cell lines Brown preadipocytes
Concentrations 2 nM
Incubation Time 2 days
Method

Brown preadipocytes were isolated from perirenal adipose tissues of Chuanzhong black goats (1 day after birth). The cells were cultured in DMEM/F12 containing 10% fetal bovine serum and 2% penicillin/streptomycin and placed in an incubator (5% CO2, 37°C). Until 100% confluence, DMEM/F12 was supplemented with 2% FBS containing 5 μg/ml of insulin, 1 μM dexamethasone, 0.5 mM IBMX, 1 μM Rosiglitazone, and 2 nM triiodothyronine to induce brown adipocytes differentiation. Two days later, the induced medium was changed to a maintenance medium (DMEM/F12 supplemented with 2% FBS, 5 μg/ml of insulin, and 2 nM triiodothyronine). Cells were harvested 8 days after differentiation. L-carnitine was added to the medium throughout the differentiation process and supplemented at 600 μΜ. SiAMPKα (GAAGAGAAATTCAGAACCT)15 were transfected by Lipofectamine 3000. Lipid droplets were stained using Oil Red O solution. After staining, 1 ml isopropanol was used to dissolve the oil red O dye, and the absorbance at 510 nm was detected.

(Data sourced from selleck products)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05574712 Not yet recruiting
Prostate Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 January 1 2024 Phase 2
NCT06067529 Not yet recruiting
Premature Ovarian Insufficiency
Women''s Hospital School Of Medicine Zhejiang University
 November 1 2023 --
NCT06134258 Recruiting
Fasting
ETH Zurich|University Hospital Basel Switzerland
 November 15 2023 Not Applicable
NCT06072885 Recruiting
Postoperative Pulmonary Atelectasis
Istanbul University
 October 15 2023 --

Chemical Information & Solubility

Molecular Weight 650.97 Formula

C15H12I3NO4
CAS No. 6893-02-3 SDF --
Smiles C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)O)N)I)I)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (153.61 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

0.1M NAOH : 1.56 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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