Home GPCR & G Protein Prostaglandin Receptor agonist Tafluprost For research use only.

Tafluprost

Synonyms: AFP-168,MK2452

Tafluprost (AFP-168,MK2452) is a novel prostaglandin analog with a high affinity for the fluoroprostaglandin (FP) receptor PGF2α. A prostanoid selective FP receptor agonist.

Tafluprost Chemical Structure

Tafluprost Chemical Structure

CAS: 209860-87-7

Purity & Quality Control

Batch: S485101 Purity: 99.02%
99.02

Tafluprost Related Products

Choose Selective Prostaglandin Receptor Inhibitors

Biological Activity

Description Tafluprost (AFP-168,MK2452) is a novel prostaglandin analog with a high affinity for the fluoroprostaglandin (FP) receptor PGF2α. A prostanoid selective FP receptor agonist.
Targets
PGF2α [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04828057 Completed
Ocular Surface Disease|Primary Open Angle Glaucoma
Santen Pharmaceutical (Taiwan) Co. LTD
 September 1 2021 --
NCT03612817 Completed
Glaucoma Open-Angle
Aristotle University Of Thessaloniki|Santen Oy
 January 2017 Phase 4
NCT02102750 Completed
Glaucoma|Ocular Hypertension
Santen Oy
 June 2014 Phase 1
NCT03104621 Completed
Primary Open-angle Glaucoma
Gangnam Severance Hospital
 March 2013 Phase 4

Chemical Information & Solubility

Molecular Weight 452.53 Formula

C25H34F2O5
CAS No. 209860-87-7 SDF --
Density 1.186 g/mL
Smiles CC(C)OC(=O)CCCC=CCC1C(CC(C1C=CC(COC2=CC=CC=C2)(F)F)O)O
Storage (From the date of receipt) 2 years -80°C liquid

In vitro
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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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